Molecular Formula: C6H20Cl2N4
Molecular weight: 219.15 g/mol
CAS No: 38260-01-4
ATC Code: A16AX12
Drug Class: Wilson’s Disease
General Properties:
Trientine hydrochloride is a secondary amino compound.
Trientine Hydrochloride is the hydrochloride salt form of a metal chelating agent with potential anti-angiogenic activity. Trientine chelates excess copper (Cu) ions in the body; the excess copper is subsequently removed from the body through the kidneys. As Cu is an essential cofactor for cuproenzymes, such as superoxide dismutase 1 (SOD1), depletion of copper may inhibit the activation of signal transduction pathways required for cellular proliferation and angiogenesis. In addition, trientine may inhibit copper-induced secretion of interleukin-8 (IL-8).
An ethylenediamine derivative used as stabilizer for EPOXY RESINS, as ampholyte for ISOELECTRIC FOCUSING and as chelating agent for copper in HEPATOLENTICULAR DEGENERATION.
Indication:
Trientine is used to treat Wilson’s disease, a disease in which there is high levels of copper in the body in patients who are de-coppered and dependent to penicillamine. This medicine combines with excess copper in the body and may prevent your body from absorbing the copper in the foods you eat.
