Molecular Formula: C4H6N4O3S2
Molecular weight: 222.3 g/mol
CAS No: 59-66-5
ATC Code: S01EC01
Drug Class: Glaucoma
General Properties:
Acetazolamide appears as white to yellowish-white fine crystalline powder. No odor or taste.
Acetazolamide is a sulfonamide, a member of thiadiazoles and a monocarboxylic acid amide. It has a role as a diuretic, an anticonvulsant and an EC 4.2.1.1 (carbonic anhydrase) inhibitor. It is a conjugate acid of an acetazolamide(1-). It derives from a hydride of a 1,3,4-thiadiazole.
One of the carbonic anhydrase inhibitors that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition.
Indication:
Acetazolamide Oral Tablets. Acetazolamide is a diuretic medication that treats swelling caused by heart disease. It works by helping your body make more pee so you can lose salt and excess water from your body. It can also treat seizures, certain types of glaucoma and prevent symptoms of altitude sickness.
