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ATOSIBAN ACETATE

IUPAC Name: acetic acid;(2S)-N-[(2S)-5-amino-1-[(2-amino-2-oxoethyl)amino]-1-oxopentan-2-yl]-1-[(4R,7S,10S,13S,16R)-7-(2-amino-2-oxoethyl)-13-[(2S)-butan-2-yl]-16-[(4-ethoxyphenyl)methyl]-10-[(1R)-1-hydroxyethyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]pyrrolidine-2-carboxamide

Symbol: AA

Molecular Formula: C45H71N11O14S2

Molecular weight: 1054.2 g/mol

CAS No: 914453-95-5

ATC Code: G02CX01

Drug Class: Vasopressin Inhibitor

General Properties:

Atosiban reduces the frequency of uterine contractions to delay pre-term birth in adult females and induces uterine quiescence 5,1. Atosiban is a synthetic peptide oxytocin antagonist 5,1. It resembles oxytocin with has modifications at the 1, 2, 4, and 8 positions.

Indication:

Atosiban is an inhibitor of the hormones oxytocin and vasopressin. It is used intravenously to halt premature labor. Although initial studies suggested it could be used as a nasal spray and hence would not require hospital admission, it is not used in that form.

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