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FERRIC CARBOXYMALTOSE

IUPAC Name: (2S,3S,4S,5R)-4-[(2R,3R,4R,5S,6R)-5-[(2R,3R,4R,5S,6R)-3,4-dihydroxy-6-(hydroxymethyl)-5-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-3,4-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2,3,5,6-tetrahydroxyhexanoate;iron(3+);oxygen(2-);hydroxide;hydrate

Symbol: FC

Molecular Formula: C24H44FeO25-

Molecular weight: 788.152102 g/mol

CAS No: 9007-72-1

Drug Class: Haematinic

General Properties:

Ferric carboxymaltose is an iron replacement product and, chemically, an iron-carbohydrate complex.

Ferric Carboxymaltose is a parenteral iron solution containing ferric iron complexed with carboxymaltose polymers, used in parenteral iron-replacement therapy. Upon administration, ferric carboxymaltose is removed from plasma by the reticuloendothelial system. Subsequently, ferric iron binds to transferrin or is stored as ferritin. Transferrin-bound iron is transported in the plasma to the liver, spleen and bone marrow, where it is incorporated into hemoglobin, and to muscle, where it is incorporated into myoglobin.

Indication:

Ferric carboxymaltose is an iron replacement product indicated for the treatment of iron deficiency anemia in patients ≥1 year of age who have an intolerance to, or unsatisfactory response from, oral iron therapy, and in adult patients who have non-dialysis-dependent chronic kidney disease. It is also indicated to treat iron deficiency and improve exercise capacity in adult patients with NYHA class II or III heart failure.

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